NCDIR Team

The National Center for Dynamic Interactome Research couples together an established mass spectrometry resource, a cell biology / protein chemistry laboratory, a high-throughput systems biology resource, and a computational biology center. The team which oversees the various technology cores in this center is made of acknowledged experts in their respective fields. Thus, the Cell Biology and Biochemistry Core is supervised by Michael Rout, who is a pioneer in subcellular fractionation and the elucidation of macromolecular structures through the affinity purification of proteins. In particular, he is most noted for his studies on the nuclear pore complex and yeast spindle organizer. The Macromolecular Analysis Core is divided into two subsections: a Mass Spectrometry Core Subsection overseen by Brian Chait, and a Microarray Core Subsection overseen by John Aitchison. Brian Chait is a leader in biological mass spectrometry, having designed and constructed many new mass spectrometers (18 U.S. patents) and developed numerous groundbreaking mass spectrometry – based techniques for the identification, characterization and quantitation of macromolecules. John Aitchison is a founding member of the Institute for Systems Biology where he exploits the tools of systems biology for the study the cell biology, organelle biogenesis and nuclear transport. He is co-inventor of genomic tagging and isolation procedures, which lie at the heart of this proposal and is a leader in the fields of yeast genetics, molecular biology, and microarray technologies. Andrej Sali, who will direct the Bioinformatics Core, is one of the pre-eminent figures in computational structural biology. His work is focused on using computation, grounded in the laws of physics and evolution, to study the structure and function of proteins, leading to structure-based functional annotation of proteins and macromolecular complexes. His structure modeling programs are widely used by the scientific community.

For more detailed information on the specific research please visit our research section.

Contact Information

PRINCIPAL INVESTIGATOR:
Michael Rout,
Professor