Courses & Video Resources
WEBINARS
Experimental methods for identifying synergistic nanobody combinations that neutralize SARS-CoV-2
Nanobodies can bind to viral antigens in places not accessible to human antibodies and are considerably more thermo-resistant. We have generated a repertoire containing >100 nanobodies against the spike protein of SARS-CoV-2. In this webinar, we will discuss the advantages of nanobodies and our methods to characterize their neutralizing activity, including use of liquid-handling robots and methods to readout neutralization efficacy. Using these methods we have identified several nanobody combinations that display drug-like synergy, enhancing neutralizing activity far greater than expected by additive activity alone. These results offer insights into optimal design principles for developing highly effective and variant-resistant COVID-19 therapeutics.
Disrupting life science: How VHH antibodies will shape future research (registration required)
For over 25 years, researchers have explored how nanobodies can be utilized in many life science fields. They have been found to be particularly powerful as imaging tools to visualize developing structures and pathologies with greater resolution. VHH antibodies have been used to characterize protein conformation and ligand and receptor relationships. Numerous pharmaceutical applications have been pursued, from diagnosis and therapy to follow-up. Potential treatment uses for nanobodies include solid tumor cancers, Alzheimer’s disease, and even COVID-19. In 2019, the U.S. Food and Drug Administration approved caplacizumab, the first nanobody for the prevention of thrombosis in patients with acute coronary syndrome.
In this webinar, our diverse panel of thought leaders will discuss the potential impact of VHH antibodies on life science research and touch on how these tools will transform technologies for imaging, diagnostics, and therapeutics.
This webinar will last for approximately 60 minutes.
In this webinar, our diverse panel of thought leaders will discuss the potential impact of VHH antibodies on life science research and touch on how these tools will transform technologies for imaging, diagnostics, and therapeutics.
This webinar will last for approximately 60 minutes.
www.science.org
Integrative Structural Biology Webinars | Thermo Fisher Scientific - US (registration required)
Integrative structural biology combines structural and functional information from various techniques, including cryo-electron microscopy (cryo-EM) and mass spectrometry (MS), to arrive faster at a more complete picture of a protein and its function.
Register now to access our growing library of integrative structural biology webinars and find out how this approach can help you answer your most challenging biological questions.
Register now to access our growing library of integrative structural biology webinars and find out how this approach can help you answer your most challenging biological questions.
VIDEO TUTORIALS
Harvesting cells & Making noodles
Cryogenic disruption of yeast cells using a PM100 ball mill
Journal of Visualized Experiments (JoVE) protocols
