Funded by a grant from the National Institutes of General Medical Sciences of the National Institute of Health

Welcome to the NCDIR!

The National Center for Dynamic Interactome Research (NCDIR) is a Biotechnology Resource Center funded by the NIH. We are four labs across the USA carrying out cutting-edge research in the fields of molecular and cellular biology. We are at the forefront of methodological and technology development to aid researches in both the medical and general sciences. Welcome and explore!



April 8th, 2021 – Research Spotlight!

New Publication!

A landmark structural biology paper on understanding how a transcription-coupled repair protein disassembles a stalled transcription complex was recently published from the lab of Seth Darst and Elizabeth Campbell with the help of NCDIR scientist Dom Olinares from Brian Chait’s Lab. Read more.

February 13th, 2021 – Research Spotlight

New publication!

  A native mass spectrometry (nMS)-based platform developed at the NCDIR for evaluating and optimizing sample quality for single particle cryogenic microscopy (cryo-EM). Read more here

September 30th, 2020 – Research Spotlight!

New Publication!

Read more about how NCDIR scientists helped illuminate how a class of viruses called enteroviruses disrupt the machinery of normal human host cells during infection

August 16th, 2020 – Research Spotlight!

New Publication!

NCDIR scientists propose new strategies to develop antiviral therapeutics.
Read more…

January 30th, 2020 – Research Spotlight!

New Publication!

Structural basis of substrate recognition by a polypeptide processing and secretion transporter. More info and full text here!

May 13th, 2020 – Research Spotlight!

New publication!

NCDIR scientists have developed ODELAM, a technique to study drug resistance in Mycobacterium tuberculosis. More info and full text here!


Intergrative Modeling Platform

The Integrative Modeling Platform (IMP) allows comprehensive structural characterization of biomolecules ranging from small molecules to massive macromolecular complexes. IMP provides an open source C++ and Python toolbox for solving complex modeling problems, and a number of applications for tackling some common problems in a user-friendly way.


The NCDIR is actively optimizing the pipeline for the production of nanobodies, highly interesting naturally occurring antibody variants isolated from Camelids. These 15 kDa antibody fragments are the  topic  of  intense research as a tool for basic and clinical research, diagnostics, and therapeutics. is an external site intended as a resource for scientists to assist with the curation of images of SDS-PAGE protein gels displaying protein co-purification banding patterns resulting from affinity capture experiments.