Welcome to the Integrative Modeling Platform (IMP)!
The goal of the Integrative Modeling Platform (IMP) is to contribute to a comprehensive structural characterization of biomolecules ranging in size and complexity from small peptides to large macromolecular assemblies. Detailed structural characterization of assemblies is generally impossible by any single existing experimental or computational method. This barrier can be overcome by hybrid approaches that integrate data from diverse biochemical and biophysical experiments (eg, x-ray crystallography, NMR spectroscopy, electron microscopy, immuno-electron microscopy, footprinting, chemical cross-linking, FRET spectroscopy, small angle X-ray scattering, immunoprecipitation, genetic interactions, etc…).
We formulate the hybrid approach to structure determination as an optimization problem, the solution of which requires three main components:
- the representation of the assembly,
- the scoring function and
- the optimization method.