Enteroviruses cause a number of human diseases including gastroenteritis, the common cold, hand-foot-and-mouth disease, acute hemorrhagic conjunctivitis, and skin rash. In this study, researchers identified which host proteins are broken apart, or “cleaved”, by proteins produced by enteroviruses. By disrupting proteins this way, these viruses remodel infected cells to avoid detection by the host’s immune system and create a favorable environment for replication. The researchers identified proteins commonly targeted across five different enteroviruses and were able to identify specific cell functions in which these proteins participate, providing valuable insight into which cellular processes are subverted or disrupted during infection. As the first global assessment of enterovirus protein cleavage in human cells, the study is the first of its kind and provides a valuable community resource for understanding enterovirus biology and for generating new approaches to combat enterovirus-related diseases.