Funded by a grant from the National Institutes of General Medical Sciences of the National Institute of Health
March 14th 2018 - Published in Nature today. NCDIR scientists have solved the structure of the largest protein complex in the cell - The Nuclear Pore complex. Read more...
The lab of Prof. John Aitchison in Seattle, WA apply systems biology approaches to the study of infectious disease agents.
The Rout lab applies structural and molecular biological techniques to study complex cellular interactions.
Welcome to NCDIR!
The National Center for Dynamic Interactome Research (NCDIR) is a Biotechnology Resource Center funded by the NIH. We are four labs across the USA carrying out cutting-edge research in the fields of molecular and cellular biology. We are at the forefront of methodological and technology development to aid researches in both the medical and general sciences. Welcome and explore!
November 9, 2017
NCDIR scientist, Dr. John LaCava on raising antibodies against protein complexes.
Read more…
Intergrative Modeling Platform
The Integrative Modeling Platform (IMP) allows comprehensive structural characterization of biomolecules ranging from small molecules to massive macromolecular complexes. IMP provides an open source C++ and Python toolbox for solving complex modeling problems, and a number of applications for tackling some common problems in a user-friendly way.
Nanobodies
The NCDIR is actively optimizing the pipeline for the production of nanobodies, highly interesting naturally occurring antibody variants isolated from Camelids. These 15 kDa antibody fragments are the topic of intense research as a tool for basic and clinical research, diagnostics, and therapeutics.
Copurification.org
Copurification.org is an external site intended as a resource for scientists to assist with the curation of images of SDS-PAGE protein gels displaying protein co-purification banding patterns resulting from affinity capture experiments.