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Funded by a grant from the National Institutes of General Medical Sciences of the National Institute of Health

The lab of Prof. John Aitchison in Seattle, WA apply systems biology approaches to the study of infectious disease agents.

The Rout lab applies structural and molecular biological techniques to study complex cellular interactions.

The Chait Lab are forerunners in broadening the scope of mass spectrometry to study complex biological systems.

The Sali Lab are leaders in developing and applying computational methods for the integrative determination of the structures and dynamics of proteins

Welcome to NCDIR!

The National Center for Dynamic Interactome Research (NCDIR) is a Biotechnology Resource Center funded by the NIH. We are four labs across the USA carrying out cutting-edge research in the fields of molecular and cellular biology. We are at the forefront of methodological and technology development to aid researches in both the medical and general sciences. Welcome and explore!



April 26, 2018

The NCDIR is in the news!
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April 20, 2018

The NCDIR is in the news!
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March 15, 2018

The NCDIR is in the news!
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Intergrative Modeling Platform

The Integrative Modeling Platform (IMP) allows comprehensive structural characterization of biomolecules ranging from small molecules to massive macromolecular complexes. IMP provides an open source C++ and Python toolbox for solving complex modeling problems, and a number of applications for tackling some common problems in a user-friendly way.


The NCDIR is actively optimizing the pipeline for the production of nanobodies, highly interesting naturally occurring antibody variants isolated from Camelids. These 15 kDa antibody fragments are the  topic  of  intense research as a tool for basic and clinical research, diagnostics, and therapeutics.


Copurification.org is an external site intended as a resource for scientists to assist with the curation of images of SDS-PAGE protein gels displaying protein co-purification banding patterns resulting from affinity capture experiments.