Funded by a grant from the National Institutes of General Medical Sciences of the National Institute of Health

Welcome to NCDIR!

The National Center for Dynamic Interactome Research (NCDIR) is a Biotechnology Resource Center funded by the NIH. We are four labs across the USA carrying out cutting-edge research in the fields of molecular and cellular biology. We are at the forefront of methodological and technology development to aid researches in both the medical and general sciences. Welcome and explore!



October 23, 2018

Drs. John LaCava and Erica Jacobs form the Rockefeller University have been selected by the RNA Society to host an RNA Society Salon in NYC during the 2018/2019 Salon calendar.
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September 21, 2018

NCDIR scientists and technology have been featured in a recent publication exploring RNA pol II repression.
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August 31st, 2018

NCDIR scientists invited to teach at the School of Molecular and Theoretical Biology in Poznań, Poland
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April 26, 2018

The NCDIR is in the news!
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April 20, 2018

The NCDIR is in the news!
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March 15, 2018

The NCDIR is in the news!
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Intergrative Modeling Platform

The Integrative Modeling Platform (IMP) allows comprehensive structural characterization of biomolecules ranging from small molecules to massive macromolecular complexes. IMP provides an open source C++ and Python toolbox for solving complex modeling problems, and a number of applications for tackling some common problems in a user-friendly way.


The NCDIR is actively optimizing the pipeline for the production of nanobodies, highly interesting naturally occurring antibody variants isolated from Camelids. These 15 kDa antibody fragments are the  topic  of  intense research as a tool for basic and clinical research, diagnostics, and therapeutics.


Copurification.org is an external site intended as a resource for scientists to assist with the curation of images of SDS-PAGE protein gels displaying protein co-purification banding patterns resulting from affinity capture experiments.